Ssa Antibody Normal Range

Ss a ro ss b la rnp and sm are autoantigens commonly referred to as extractable nuclear antigens ena.

Ssa antibody normal range.

The reference range of anti ro antibodies is negative. Sjogren s antibodies ss a ss b sjögren s antibodies ss b is detected in approximately 15 of patients with sjögren s syndrome. Ss a ro is composed of protein antigens of 52 kd and 60 kd combined with cytoplasmic rna species. Anti ssa can be found in up to 60 of people who are confirmed to have lupus.

Ss a ro antibodies are associated with childhood le neonatal le and with congenital heart block in infants born to mothers with le 1 2 ss a ro antibodies have also been reported to be associated with features of extraglandular inflammation in patients with le including vasculitis purpura cytopenias and adenopathy. Another condition called sjorgen s syndrome is also known to produce positive test results in up to 70 of people. This has been termed antiphospholipid antibody syndrome. A positive anti ro result is revealed and known by a speckled appearance under immune fluorescence with ultraviolet light.

Ss a ro is an extractable nuclear antigen ena composed of protein antigens of 52 kd and 60 kd combined with cytoplasmic rna species. Lower likelihood of anti dna antibodies. The reference range of anti ro antibodies is negative. Both anti ssa and anti ssa are usually absent in secondary sjögren s syndrome.

Anti ro antibodies also known as anti ssa antibodies are associated with sjögren syndrome. In some regions however only 1 in 4 people with lupus will have a positive test result for this antibody. Anti ro levels may be elevated in the following conditions. Anti ss a and anti ss b are found in virtually all children with neonatal lupus.

When anti ssa levels are elevated in sle it is often in antinuclear antibody ana negative lupus. Patients with ss a may also have antibodies to cardiolipin lupus anticoagulant and clinical thromboses. Ss a ro antibodies occur in patients with several different connective tissue. 25 of cases both anti ro ssa and.

Antibodies to ena are common in patients with connective tissue diseases systemic rheumatic diseases. Anti ssa plus anti la ssb is associated with the following factors. 60 70 of cases systemic lupus erythematosus sle. Age older than 50 years.

Antibodies to ss a are also associated with hla loci dr3 and dr2 and with hereditary deficiency of c2. The presence of both antibodies ss a and ss b strengthen the diagnosis of sjögren s syndrome and conveys prognostic information. Lupus erythematosus le 40 60 of. Sjögren s antibody ss b is present only if sjögren s antibody ss a is also detected.