Ssa Antibody Reference Range

Ss a ro antibodies occur in patients with several different connective tissue diseases including sjogren syndrome an autoimmune disease that involves primarily the salivary and lachrymal glands up to 90 of cases.

Ssa antibody reference range.

Anti ss a and anti ss b are found in virtually all children with neonatal lupus. Ss b la is composed of a 48 kd protein combined with rna species. Sjögren s antibody ss b is present only if sjögren s antibody ss a is also detected. A positive anti ro result is revealed and known by a speckled appearance under immune fluorescence with ultraviolet light.

This has been termed antiphospholipid antibody syndrome. Antibodies to ena are common in patients with connective tissue diseases systemic rheumatic diseases. Lupus erythematosus le 40 60 of. Anti ro antibodies also known as anti ssa antibodies are associated with sjögren syndrome.

Ss a ro ss b la rnp and sm are autoantigens commonly referred to as extractable nuclear antigens ena. Ss a ro is an extractable nuclear antigen ena composed of protein antigens of 52 kd and 60 kd combined with cytoplasmic rna species. 60 70 of cases systemic lupus erythematosus sle. The reference range of anti ro antibodies is negative.

Patients with ss a may also have antibodies to cardiolipin lupus anticoagulant and clinical thromboses. The reference range of anti ro antibodies is negative. Ss a ro antibodies are associated with childhood le neonatal le and with congenital heart block in infants born to mothers with le 1 2 ss a ro antibodies have also been reported to be associated with features of extraglandular inflammation in patients with le including vasculitis purpura cytopenias and adenopathy. The presence of both antibodies ss a and ss b strengthen the diagnosis of sjögren s syndrome and conveys prognostic information.

Anti ro levels may be elevated in the following conditions. Sjogren s antibodies ss a ss b sjögren s antibodies ss b is detected in approximately 15 of patients with sjögren s syndrome. Ss b la antibodies are found primarily in patients with sjogren syndrome or le where they occur with frequencies of approximately 60 and 15 respectively 1 2 ss b la antibodies occur only infrequently in the absence of ss a ro antibodies. Ss a ro antibodies occur in patients with several different connective tissue.